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When applied to the skin, Solaraze gel is used to treat a skin problem known as actinic or solar keratosis that is caused by long-term sun exposure. Due to the low systemic absorption of Solaraze, overdosage is extremely unlikely as a result of topical use. There have been no clinical cases of ingestion of Solaraze inducing overdosage. • Inhibition of prostaglandin synthesis may adversely affect the pregnancy and/or the embryo/foetal development.
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Diclofenac inhibited ovulation in the rabbit and impaired implantation, as well as early embryonic development in the rat. The embryo/foeto-toxic potential of diclofenac was evaluated in three animal species (rat, mouse and rabbit). Foetal death and growth retardation occurred at maternal toxic doses, however, on the basis of the available data, diclofenac is not considered to be teratogenic. The gestation period and the duration of parturition were extended by diclofenac. Doses lower than maternal toxic ones did not affect the postnatal development.
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